The Diadenosine Polyphosphates Ap,A and Ap,A and Adenosine Triphosphate Interact With Granulocyte-Macrophage Colony-Stimulating Factor to Delay Neutrophil Apoptosis: Implications for Neutrophi1:Platelet Interactions During Inflammation
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چکیده
Incubation of neutrophils with cytokines such as granulocyte macrophage colony-stimulating factor (GM-CSF) delays their loss of function and changes in cellular morphology that are characteristic of apoptosis. Adenosine triphosphate (ATP) and the diadenosine polyphosphates Ap,A and Ap,A were almost as effective as GM-CSF in delaying neutrophil apoptosis. The nucleotides could thus preserve cellular morphology, protect against chromatin fragmentation, and preserve functions such as NADPH oxidase activity and expression of CD16. Moreover, addition of ATP, Ap,A, and
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تاریخ انتشار 2002